SEC EDGAR · Insider purchase
NTHI: CHEN THOMAS C reported buying shares
2 reported purchases of non-derivative securities. Code P includes open-market and private purchases; it does not establish motive.
Follow NTHI- Became public
- Nov 12, 2026, 6:15 AM EST
- Event / period date
- Nov 9, 2026
- Collected
- Nov 12, 2026, 6:16 AM EST
Why this is connected
This filing identifies NEONC TECHNOLOGIES HOLDINGS, INC. as the issuer of the security. The company's SEC identifier connects it to NTHI.
Reported transactions
CHEN THOMAS C (CMO)
2,732 shares · Common Stock
Nov 9, 2026 · $3.66 per share
2,284 shares · Common Stock
Nov 10, 2026 · $4.379 per share
Value calculated from the reported shares and prices: $20,000.76.
Code P covers open-market and private purchases. Grants, option exercises, and tax withholding are excluded from purchase results. Read the source footnotes for ownership and pricing details.
Source evidence
Read the source excerpt or record
<?xml version="1.0"?>
<ownershipDocument>
<schemaVersion>X0609</schemaVersion>
<documentType>4</documentType>
<periodOfReport>2026-11-09</periodOfReport>
<issuer>
<issuerCik>0001979414</issuerCik>
<issuerName>NEONC TECHNOLOGIES HOLDINGS, INC.</issuerName>
<issuerTradingSymbol>NTHI</issuerTradingSymbol>
<issuerForeignTradingSymbol></issuerForeignTradingSymbol>
</issuer>
<reportingOwner>
<reportingOwnerId>
<rptOwnerCik>0001998682</rptOwnerCik>
<rptOwnerName>CHEN THOMAS C</rptOwnerName>
</reportingOwnerId>
<reportingOwnerAddress>
<rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
<rptOwnerStreet1>23975 SORRENTO PARK</rptOwnerStreet1>
<rptOwnerStreet2>SUITE 205</rptOwnerStreet2>
<rptOwnerCity>CALABASAS</rptOwnerCity>
<rptOwnerState>CA</rptOwnerState>
<rptOwnerZipCode>91302</rptOwnerZipCode>
<rptOwnerStateDescription></rptOwnerStateDescription>
</reportingOwnerAddress>
<reportingOwnerRelationship>
<isDirector>true</isDirector>
<isOfficer>true</isOfficer>
<isTenPercentOwner>true</isTenPercentOwner>
<isOther>false</isOther>
<officerTitle>CMO</officerTitle>
<otherText></otherText>
</reportingOwnerRelationship>
</reportingOwner>
<aff10b5One>0</aff10b5One>
<nonDerivativeTable>
<nonDerivativeTransaction>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<transactionDate>
<value>2026-11-09</value>
</transactionDate>
<deemedExecutionDate></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>P</transactionCode>
<equitySwapInvolved>false</equitySwapInvolved>
</transactionCoding>
<transactionTimeliness></transactionTimeliness>
<transactionAmounts>
<transactionShares>
<value>2732</value>
</transactionShares>
<transactionPricePerShare>
<value>3.66</value>
</transactionPricePerShare>
<transactionAcquiredDisposedCode>
<value>A</value>
</transactionAcquiredDisposedCode>
</transactionAmounts>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>27235</value>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By IRA</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeTransaction>
<nonDerivativeHolding>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>583531</value>
<footnoteId id="F1"/>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value>
</directOrIndirectOwnership>
</ownershipNature>
</nonDerivativeHolding>
<nonDerivativeHolding>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>261242</value>
<footnoteId id="F2"/>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By HCWG LLC</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeHolding>
<nonDerivativeHolding>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>888148</value>
<footnoteId id="F3"/>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By NeuCen Biomedical Co. Ltd.</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeHolding>
<nonDerivativeHolding>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>2833961</value>
<footnoteId id="F4"/>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By TR Chen Third Family Limited Partnership.</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeHolding>
<nonDerivativeHolding>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>93253</value>
<footnoteId id="F5"/>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By Tien Duan Chen Trust</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeHolding>
<nonDerivativeHolding>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>948</value>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By Defined Benefit Plan</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeHolding>
<nonDerivativeTransaction>
<securityTitle>
<value>Common Stock</value>
</securityTitle>
<transactionDate>
<value>2026-11-10</value>
</transactionDate>
<deemedExecutionDate></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>P</transactionCode>
<equitySwapInvolved>false</equitySwapInvolved>
</transactionCoding>
<transactionTimeliness></transactionTimeliness>
<transactionAmounts>
<transactionShares>
<value>2284</value>
<footnoteId id="F6"/>
</transactionShares>
<transactionPricePerShare>
<value>4.379</value>
<footnoteId id="F7"/>
</transactionPricePerShare>
<transactionAcquiredDisposedCode>
<value>A</value>
</transactionAcquiredDisposedCode>
</transactionAmounts>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>29519</value>
</sharesOwnedFollowingTransaction>
</postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>I</value>
</directOrIndirectOwnership>
<natureOfOwnership>
<value>By IRA</value>
</natureOfOwnership>
</ownershipNature>
</nonDerivativeTransaction>
</nonDerivativeTable>
<derivativeTable></derivativeTable>
<footnotes>
<footnote id="F1">Includes shares of common stock held by certain members of Reporting Person's immediate family of which Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest, if any, therein.</footnote>
<footnote id="F2">Such shares represent only Reporting Person's percentage interest in HCWG LLC.</footnote>
<footnote id="F3">Shares held by NeuCen Biomedical Co. Ltd., which is owned in part by Reporting Person's spouse. Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest, if any, therein.</footnote>
<footnote id="F4">Shares held by T. R. Chen Third Family Limited Partnership, a NV limited partnership, of which Reporting Person and his spouse are the general partners with sole voting and dispositive power. Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest, if any, therein.</footnote>
<footnote id="F5">Reporting Person disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest, if any, therein.</footnote>
<footnote id="F6">The aggregate number of shares (the "Shares") of common stock of Issuer purchased by the Reporting Person on the same date at different prices.</footnote>
<footnote id="F7">Represents the weighted average purchase price. The Shares were purchased at prices ranging from $4.31 to $4.38 per share, inclusive. Full information regarding the number of Shares sold at each price shall be provided to the Securities and Exchange Commission staff, Issuer or any security holder, upon request.</footnote>
</footnotes>
<remarks></remarks>
<ownerSignature>
<signatureName>/S/ THOMAS C CHEN</signatureName>
<signatureDate>2026-11-12</signatureDate>
</ownerSignature>
</ownershipDocument>Original documents control. Public records can be amended, and company connections may require interpretation. Nothing here is investment advice.